What Are Cell Cycle Inhibitors and How Do They Work?
Jul 27, 2025 · Cell cycle inhibitors are substances that stop or slow down the cell cycle, the series of steps a cell goes through as it grows and divides. They control cell division, preventing uncontrolled …
Inhibitors of Cyclin-Dependent Kinases: Types and Their Mechanism …
Recent studies on cyclin-dependent kinase (CDK) inhibitors have revealed that small molecule drugs have become very attractive for the treatment of cancer and neurodegenerative disorders. Most CDK …
Cell Cycle Inhibitors - Tocris Bioscience
Cell cycle inhibitors slow or stop cell cycle progression through various mechanisms. Cell cycle arrest can be induced at different stages, decreasing the rate of cell division and the number of actively …
The pathophysiology of the cell cycle in cancer and treatment ...
Nov 1, 2023 · To combat the dysregulation of the cell cycle in cancer, various therapeutic strategies have been developed, including CDK inhibitors, cyclin inhibitors, and checkpoint activators.
What are the Types of Cell Cycle Inhibitors?
There are several types of cell cycle inhibitors, including: 1. CDK Inhibitors: Target specific CDKs to halt cell cycle progression. 2. Cyclin Inhibitors: Bind to cyclins to prevent their interaction with CDKs. 3. …
Immunomodulation by anticancer cell cycle inhibitors - Nature
Apr 28, 2020 · In this Review, we discuss the ability of anticancer cell cycle inhibitors to modulate various immune functions in support of effective antitumour immunity.
Cell cycle inhibitors | PLOS One
A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206 Paige M. Chorner, Roger A. Moorehead
Development of cell-cycle inhibitors for cancer therapy - PMC
Several drugs targeting the cell cycle have entered clinical trials. These agents include flavopiridol, indisulam, AZD5438, SNS-032, bryostatin-1, seliciclib, PD 0332991, and SCH 727965. Phase i …
Cell cycle regulation and anticancer drug discovery
Nov 1, 2017 · In this review, we discuss the mechanisms underlying cell cycle regulation and present small-molecule anticancer drugs that are under development, including both pan-CDK inhibitors and …
Development of Cell-Cycle Inhibitors for Cancer Therapy - MDPI
Dec 2, 2008 · Several drugs targeting the cell cycle have entered clinical trials. These agents include flavopiridol, indisulam, AZD5438, SNS-032, bryostatin-1, seliciclib, PD 0332991, and SCH 727965. …