openheart.bmj

Open Heart

is an open access journal by BMJ and BCS, publishing original research in cardiovascular medicine. Open Heart considers submissions of a variety of article types, including original research articles, ...
Open Heart

Long-term incidence and risk factors of atrial fibrillation after percutaneous patent foramen ovale occlusion: a retrospective cohort study

Background Percutaneous patent foramen ovale (PFO) closure is an established intervention for secondary prevention of ...
Open Heart

Development of a heart failure with preserved ejection fraction risk prediction score in primary care settings with a high HIV prevalence

Background Antiretroviral therapy (ART)-treated people with HIV (PWH) have increased risk of heart failure with preserved ...
Open Heart

Ultra-rapid outpatient treatment of patients with severe aortic stenosis presenting with acute valve syndrome: evaluation of a novel pathway for urgent TAVI

Background Up to 30% of patients undergoing transcatheter aortic valve implantation (TAVI) have presented to hospital with ...
Open Heart

Does increasing model complexity improve HEART-based chest pain risk stratification? A multicentre development and held-out emergency department vali…

Background and objectives The History, ECG, Age, Risk factors and Troponin (HEART) score is widely used for emergency ...
Open Heart

Nationwide LDL-C goal attainment in high-risk and very-high-risk patients in Denmark: real-world lipid management and simulated impact of guideline implementation

Aim Low-density lipoprotein cholesterol (LDL-C) goal attainment remains suboptimal among individuals with or at risk for atherosclerotic cardiovascular disease (ASCVD). We evaluated contemporary ...
openheart.bmj

Table of contents

APCU25CR28 Navigating dual diagnosis: case report of amyloid transthyretin (ATTR) cardiac amyloidosis and amyloid light-chain (AL) (13 February, 2026) ...
openheart.bmj

Prevalence and incidence of amyloid transthyretin amyloidosis in the USA: insights from claims databases and electronic health records

Background Amyloid transthyretin (ATTR) amyloidosis is a rare, life-threatening disease frequently manifesting with cardiomyopathy (ATTR-CM), polyneuropathy (ATTR-PN) or both (ATTR-mixed). We ...
openheart.bmj

Representation of women in cardiovascular disease management: a systematic analysis of ESC guidelines

Objective Sex differences play a critical role in the presentation, progression and treatment outcomes of cardiac diseases. However, historical male predominance in clinical studies has led to ...
openheart.bmj

Survival, adverse events and management of silent in-hospital coronary bypass graft occlusion

Objectives To assess mid-term outcomes in patients with early silent coronary bypass occlusion. Methods 292 consecutive patients who underwent isolated coronary artery bypass grafting (CABG) between ...
openheart.bmj

Patterns of systolic blood pressure response at the end of exercise and mortality and morbidity in patients referred for exercise testing

Objectives Peak exercise systolic blood pressure (SBP) is associated with future cardiovascular disease (CVD) and mortality. We aimed to evaluate the predictive value of different SBP patterns at the ...
openheart.bmj

Efficacy of cardiac myosin inhibitors mavacamten and aficamten in hypertrophic cardiomyopathy: a systematic review and meta-analysis of randomised controlled trials

Background Unlike other suggested therapies, myosin inhibitors have been shown to change the course of hypertrophic cardiomyopathy by altering the contractile mechanics of cardiomyocytes. This ...