49ers head coach Kyle Shanahan confirmed defensive end Nick Bosa will miss multiple weeks after injuring his calf before Thursday's practice.

Nick Bosa has hit another setback, and this one leaves San Francisco with a much thinner defensive line. The five-time Pro Bowler pulled his calf during Thursday’s practice and is officially out for Sunday’s game against Arizona.

Nick Bosa may avoid a trip to the injured reserve after pulling his calf in Thursday’s practice, but that is not necessarily a reason for fans to celebrate. The San Francisco 49ers are simply running out of room for sidelined players.

THE girlfriend of San Francisco 49ers star Nick Bosa was seen sizzling while on the sidelines of their clash against the Miami Dolphins. The 49ers were playing their first home game of the season