Week 2 of the 2026 NFL season begins on Thursday, Sept. 17, with Thursday Night Football featuring the Detroit Lions and Buffalo Bills. There were plenty of surprising results in Week 1, and even though bettors might be leaning towards conventional wisdom for Week 2,

Matthew Stafford and the Rams offense struggled in Week 1, but there are reasons for confidence in a bounce-back performance against the Giants.

Richard Sherman wasn't happy with how Rams defensive coordinator Chris Shula utilized new CBs Trent McDuffie and Jaylen Watson in Week 1.

The Los Angeles Rams host the New York Giants at SoFi Stadium on Sept. 21 and USA TODAY's NFL experts have locked in their picks for the action.

Los Angeles Rams vs New York Giants picks, predictions, odds, win probabilities for NFL Week 2 Monday Night Football game on Sept. 21, 2026. Who wins?

Check out our experts' picks for every game in Week 2 of the 2026 NFL regular season.

Davante Adams understands the concern fans have about the Los Angeles Rams after their shocking loss to the San Francisco 49ers to begin the 2026 NFL season. Los Angeles entered the campaign as Super Bowl contenders.

Are the Niners the best team in the NFL after 1 week?

Coleman Shelton and Warren McClendon Jr. were among the best run blockers in the NFL this past week, ranking 4th at their respective positions.

Giants RB Cam Skattebo isn't backing down from Aaron Donald, and he has a pointed message for the future Hall of Famer.