Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled ...

The Indian Health Service has limited options for recruiting physicians to its most understaffed sites. Partnerships with academic medical centers could help address long-standing physician shortages.

Trichodysplasia spinulosa–associated polyomavirus was identified as a likely cause of neuroinvasive infection in a ...

Progress against the U.S. HIV epidemic is stalling, owing in part to government attacks and fear. But clinicians, patients, and activists can learn from the epidemic’s early heroes and find ways ...

A 72-year-old man with hypertension, hyperlipidemia, and a stable ascending aortic aneurysm presented with sudden-onset, ...

A 65-year-old man was admitted to this hospital because of fever, intermittent abdominal pain, and rash. The fever began 5 weeks earlier, and palpable purpura developed 1 week before admission. A ...

A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing ...

For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of ...

Panel A shows the geographic distribution of ticks and patients infected with ALTNV. The table shows areas where ticks were sampled and the prevalence of ALTNV RNA positivity among sampled ticks, and ...

In a phase 1a trial, one-time CRISPR-Cas9 gene editing with CTX310 was associated with no treatment-related dose-limiting toxic effects and with sustained reductions in ANGPTL3 and atherogenic lipi ...

In patients with syncope who present to the emergency department for evaluation, diagnosing an underlying cardiac arrhythmia remains difficult. We conducted an open-label, randomized, controlled trial ...

The safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We ...