Open Heart

Prevalence of aortic findings among patients with multifocal fibromuscular dysplasia (FMD) seen at a specialised referral centre

Background Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that affects medium-sized arteries with multifocal (beaded) or focal stenotic lesions, aneurysms, dissections and ...
Open Heart

Association between delayed transcatheter aortic valve replacement beyond 6 months and clinical outcomes in severe aortic stenosis: a retrospective observationa…

Objective Early intervention for asymptomatic severe aortic stenosis (AS) has shown prognostic benefits; however, some ...
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Open Heart

is an open access journal by BMJ and BCS, publishing original research in cardiovascular medicine. Open Heart considers submissions of a variety of article types, including original research articles, ...
Open Heart

Development of a heart failure with preserved ejection fraction risk prediction score in primary care settings with a high HIV prevalence

Background Antiretroviral therapy (ART)-treated people with HIV (PWH) have increased risk of heart failure with preserved ...
Open Heart

Long-term incidence and risk factors of atrial fibrillation after percutaneous patent foramen ovale occlusion: a retrospective cohort study

Background Percutaneous patent foramen ovale (PFO) closure is an established intervention for secondary prevention of ...
Open Heart

Ultra-rapid outpatient treatment of patients with severe aortic stenosis presenting with acute valve syndrome: evaluation of a novel pathway for urgent TAVI

Background Up to 30% of patients undergoing transcatheter aortic valve implantation (TAVI) have presented to hospital with ...
Open Heart

Does increasing model complexity improve HEART-based chest pain risk stratification? A multicentre development and held-out emergency department vali…

Background and objectives The History, ECG, Age, Risk factors and Troponin (HEART) score is widely used for emergency ...
Open Heart

Nationwide LDL-C goal attainment in high-risk and very-high-risk patients in Denmark: real-world lipid management and simulated impact of guideline implementation

Aim Low-density lipoprotein cholesterol (LDL-C) goal attainment remains suboptimal among individuals with or at risk for atherosclerotic cardiovascular disease (ASCVD). We evaluated contemporary ...
openheart.bmj

Validity, reliability and clinical utility of the Glittre ADL test in patients with atrial fibrillation

Background Activities of daily living (ADL) are frequently impaired in patients with atrial fibrillation (AF). Although the 6-Minute Walk Test (6MWT) is widely used for functional assessment, it ...
openheart.bmj

Genotype-phenotype correlations in patients with pathogenic/likely pathogenic titin variants from the Swiss Arrhythmogenic Cardiomyopathy Registry

Background Truncating variants in the titin gene (TTNtv) are associated with cardiomyopathy, mainly dilated cardiomyopathy (DCM). The clinical presentation and outcomes of arrhythmogenic phenotypes in ...
openheart.bmj

Table of contents

APCU25CR28 Navigating dual diagnosis: case report of amyloid transthyretin (ATTR) cardiac amyloidosis and amyloid light-chain (AL) (13 February, 2026) ...