Stop me if you have heard this before, but the San Francisco 49ers have multiple players being held out of their first practice of the week. It's nothing new fo

The 49ers have six players on their report with injuries, and five have no game status designation while fully practicing Friday. Only starting cornerback Deommodore Lenoir is questionable. He was added to the report as limited Thursday with a calf injury suffered in practice and did not practice Friday.

The San Francisco 49ers released their latest injury updates headed into the Week 12 contest versus the Carolina Panthers.

In what has become a minor miracle for the San Francisco 49ers this season, they managed to get through two days of practice without any injury updates.

The Arizona Cardinals are back in action in Week 11, facing the San Francisco 49ers for the second time this season. The 6-4 49ers and 3-6 Cardinals kick off from State Farm Stadium in Glendale, Arizona at 4:05 p.m. ET (2:05 p.m. Arizona time).

The Carolina Panthers (6-5) are monitoring nine players on the injury report, including Bryce Young, as they prepare for a Monday, Nov. 24 matchup against the San Francisco 49ers (7-4) at Levi's Stadium, which starts at 8:15 p.m. ET.

A new report indicates the San Francisco 49ers will release Brandon Aiyuk, who is choosing not to play for the team any longer.