Malaria represents one of the most serious threats to human health worldwide, and preventing and curing this parasitic disease still depends predominantly on the administration of a small number of ...

Serendipity is to thank for several ground-breaking discoveries and treatments, such as Alexander Fleming’s accidental discovery of penicillin. 1 However, most drug breakthroughs stem from systematic ...

Brain cells that promote tumor expansion for aggressive cancers such as glioblastoma can be “flipped” to instead inhibit that ...

Researchers are able to test in parallel the effects of over 1500 active substances on cell metabolism. Their analysis also led to the discovery of previously unknown mechanisms for known medications.

Studies reveal the therapeutic mechanism of action for levetiracetam to prevent the production of Aβ and, consequently, downstream irreversible damage.

The findings show diligence from the FDA and a need for clinicians to discuss risks, benefits, and unknowns with patients before using drugs with accelerated approval.