Ozempic has been making headlines for its remarkable success in treating obesity and diabetes. Yet it is just one in a ...

Cyclic peptides offer enhanced stability and bioavailability, but precise cyclization strategies and specialized synthetic techniques are required to maintain their biological activity. A recent ...

What is it? As the name suggests, nonribosomal peptide synthesis (NRPS) generates polypeptides sans ribosome. The resultant peptides, generally short oligomers of two to perhaps 48 residues, are not ...

Synthetic peptides, generally less than 20 amino acids in length, are essential reagents for a wide range of studies and one of the fundamental tools of proteomics researchers. Applications include ...

A major problem in solid-phase peptide synthesis (SPPS) is aggregation and poor solvation leading to incomplete deprotection and/or coupling steps, resulting in low crude purity peptides. 1 This ...

Therapeutic peptides constitute an unusual drug category. Although most therapeutic peptides are synthetic, their molecular weights are well above those of small-molecule drugs, but well below those ...

A peptide sequence that performs well at micromole scale may behave unpredictably at gram or kilogram scale. Coupling efficiency, acceptable with high reagent excess, can drop when equivalents are ...

A recent video produced by Vapourtec highlights the patented automatic Variable Bed Flow Reactor (VBFR) demonstrating fully automated solid phase peptide synthesis. The process begins with swelling ...