CHAMPAIGN, Ill. — Depression is a complex condition correlated with multiple differences in brain function and mechanisms. A new paper spanning known data about the neurotransmitter GABA and its ...
Contrary to previous research, γ-aminobutyric acid type A (GABA A) receptors are not deficient in the brains of adults with autism spectrum disorder (ASD), although GABA signaling may be functionally ...
Researchers have long believed that autism spectrum disorder is caused by some sort of imbalance between excitation and inhibition in the brain. In particular, studies have suggested that something is ...
The major inhibitory amino acid transmitter within the mammalian central nervous system (CNS) is GABA. Largely all of the brain’s neurons respond to GABA, while approximately 20% use it as their ...
What do sedatives, general anesthetics, anti-anxiety drugs, alcohol, numerous recreational drugs, and allopregnanolone, a neurosteroid being tested in Alzheimer’s trials, have in common? They all ...
People with the inherited disorder myotonic dystrophy (DM) often experience excessive daytime sleepiness and fatigue, as well as altered responses to anesthetics that can put them at risk for ...
Despite the importance of γ-aminobutyric acid type A (GABA A) receptors as drug targets for a wide range of health conditions, a crystal structure has never been determined—until now. Paul S. Miller ...
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability. The cause, which has been well-studied, is the loss of fragile X mental retardation protein (FMRP)—a genetic ...
Though Aβ tends to hog the research spotlight, scientists have steadily built a case for the importance of another APP fragment—secreted APP. Now, a paper in the January 11 Science explains how it ...
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